February 2nd, 6-10pm. Fundraiser event at Tilted Axes in West Chester, Pennsylvania. Axe Throwing event includes food, wine, and beer and a silent auction.
Click here to buy tickets.
We are thrilled to announce another great addition to our professional advisory board, Jaysson Eicholtz. We met Jaysson through a discussion about gene therapy vector (virus) manufacturing and he has now kindly volunteered his expertise, we know he will be a valuable addition.
Check out his bio and all our advisors here:
nf2biosolutions.org/about-us/professional-advisory-board/
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Jaysson graduated with a Degree in Animal Science from the University of Maryland at College Park and has a Masters in Biotechnology from the University of Maryland, University College. 20 years of experience in operations and production management roles in FDA regulated industry including vaccines, immunotherapy, and gene therapy. Helped direct and expand the production facility at Nationwide Children’s Hospital supporting gene therapy productions for multiple phase 1/2a trials. Currently is a member for the FDA Medical Devices Good Manufacturing Practice (GMP) Advisory Committee and is the Vice President of Chemistry, Manufacturing, and Controls for Scout Bio. Jaysson lives with his wife and four sons in Columbus, Ohio and is dedicated to driving down costs and barriers in gene therapy manufacturing to support research and trials for all disease indications.
nf2biosolutions.org
NF2 BioSolutions is proud to receive the support of these amazing advisors, guiding us through legal, financial and industry matters. M. Jaysson Eicholtz – FDA Advisory Committee Jaysson…"Because viruses play a central role in gene therapy, I thought it would be interesting to take a look at how viruses work. Also, what is a virus? Are viruses alive? Check out this short video. Try to understand how an AAV virus, packed with coding parts of the NF2 gene can infect Schwann Cells. What happens after the AAV virus is bound to a Schwann cell? It does as any virus would do. It injects the DNA it's carrying into the host cell. In this case a Schwann cell. In order to reproduce viruses hijack cells DNA transcription mechanisms. The video is captioned." - Margaret Reynolds, Science Of NF2What is a virus and how do they work? In the first video in the series, WinchPharma Science & Health look at viruses, how they infect cells and reproduce, as...
Looking for a new magazine read in 2019? Subscribe through Amazon Smile by January 31 and 15% will be donated to NF2 BioSolutions!
smile.amazon.com/b?node=18541223011&ref_=pe_732550_387201580
We are very excited to announce an addition to our Professional Advisory Board. Marc Hixson has extensive experience in the Pharmaceutical and Biotech industry and owns a consulting company that focuses on bringing life saving therapies to the market and to the patients who need them.
Check out his bio and all our other professional advisors here: nf2biosolutions.org/ab…/professional-advisory-board/
nf2biosolutions.org
NF2 BioSolutions is proud to receive the support of these amazing advisors, guiding us through legal, finance and industries matters. Marc Hixon – Principal, Coeus Consulting Group Marc enjoy…"The basic concept of gene therapy is simple…
1. Identify the gene that is missing in a patient suffering from a genetic disease.
2. Install this gene into the DNA of a modified virus. (A modified virus is no longer dangerous but can still infect cells.)
3. Allow this modified virus to infect the cells of the sick patient.
4. The virus inserts the missing human gene into the patients’ cells.
5. These infected cells now contain a copy of the missing gene.
6. Symptoms of the genetic disease begin to disappear.
7. The disease is considered cured. "
(1) Curran, K. (2019, January 10). The science, the history and the future of gene therapy. Retrieved from www.risingtidebio.com/what-is-gene-therapy-uses/
The science, the history and the future of gene therapy.
risingtidebio.com
The gene therapy sector is experiencing an acceleration. The FDA, EMA and China are all beginning to approve gene therapy products. Every day there's a new development. In this article, I attempt to make sense of this world. I provide a brief background on the science and then discuss both the histo...We are thrilled to announce another addition to our Scientific Advisory Board! Krizelle Alcantara has been a part of our team since the beginning and we are so happy that she has agreed to join our advisory board.
Check out her bio as well as the rest of our team here:
nf2biosolutions.org/about-us/advisory-board/
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Krizelle obtained her bachelor’s and master’s degree in Molecular Biology and Biotechnology from the University of the Philippines in Manila, Philippines. Diagnosed with NF2 in 2007, she pursued NF2 research for her BS and MS theses wherein she demonstrated the inactivation of the neurofibromin 2 tumor suppressor gene by deregulated miRNAs in cancer cells leading to enhanced oncogenicity. Upon earning her bachelor’s degree in 2012, she initially worked in a private laboratory providing genetics and cell therapy services to cancer patients. She then joined the Philippine Genome Center (PGC) in 2013 as part of the team that established the center’s DNA sequencing core facility. Under the Health Program of the PGC, she has led a cancer project which aimed to detect and characterize novel ethnicity-specific mutations among Filipino colorectal cancer patients which may serve as predictive biomarkers for response to anti-EGFR therapy. Currently, she works under a cell-based ADMET assays project as part of the drug discovery program for priority disease indications of the Philippines’ Department of Science and Technology. Krizelle hopes to use her experience as both a molecular biologist and an NF2 patient to further the molecular understanding and treatment strategies of neurofibromatosis type 2.
nf2biosolutions.org
Scientific Advisory Board: Krizelle Alcantara Krizelle obtained her bachelor’s and master’s degree in Molecular Biology and Biotechnology from the University of the Philippines in Manila, Philippin…New Paper published on Nature by Dr Brenner.
NF2 BioSolutions is accelerating this gene therapy strategy:
nf2biosolutions.org/wp-content/uploads/2019/01/Brenner-2018-Schwannoma-gene-therapy-by-AAV-delive...
nf2biosolutions.org
Older article, but this is to show that parents/patients will make it happens, they are the catalyst for gene therapy cures, this is why NF2 BioSolutions was launched. Who else has more "skin in the game" than us the parents/patients ?!
www.technologyreview.com/s/603832/determined-parents-are-moving-the-needle-on-gene-therapy/
Determined parents are moving the needle on gene therapy
technologyreview.com
Families of patients are starting advocacy groups, raising money for research, and founding biotech companies to advance cures for rare diseases.UPDATE on our Axe apparel. The sale is shortened to this weekend only so attendees of the event can receive their items in time. Here's the link again!
www.bonfire.com/axe-out-nf2/
bonfire.com
Official NF2 Axe logo wear. . About NF2 BioSolutions: Founded on June 1, 2018, NF2 BioSolutions, but actively developed since September 2018, is a 100% volunteer-run...Our Axe out NF2 clothing is ready for order on the charitable printing site Bonfire. Ordering is open until January 30th! bonfire.com/axe-out-nf2
And don’t miss our Axe Out NF2 event in West Chester PA, throwing axes with your right hand , holding a wine/beer with your left hand, tickets: www.eventbrite.com/e/axe-out-nf2-tickets-54017308223
bonfire.com
Official NF2 Axe logo wear. . About NF2 BioSolutions: Founded on June 1, 2018, NF2 BioSolutions, but actively developed since September 2018, is a 100% volunteer-run...Another example showing that families can move mountains to save their child and that gene therapy is starting to be accessible!. We are contacting these families of fighters to learn from their experience and replicate their success.
www.timesofisrael.com/to-treat-daughters-rare-genetic-disease-israeli-parents-race-to-invent-a-cu...
To treat daughter’s rare genetic disease, Israeli parents race to invent a cure
timesofisrael.com
In a Rehovot lab, scientists are working to produce a gene therapy tailor-made for 2-year-old Noga Baumatz, one of only 25-30 people in the world with the HHS genetic defectHello! year 2019 starts! NF2BioSolutions is registered as nonprofit on the corporate Benevity portal. Many corporations will match your donations to NF2BioSolutions. Check if your company uses Benevity or if it is simply matching your donations to any nonprofits.
We can't believe that 2018 is almost over! So much has happened at NF2 BioSolutions since our formation in September of 2018. We feel very blessed.
Highlights
We’ve raised over $130,000 thanks to you and people like you.
- Today we are accelerating a gene therapy initiative, of Dr Brenner, that has been shown, in mice, to kill the NF2 tumors that cause deafness, facial palsy, balance dysfunction and sometimes death (nf2biosolutions.org/research-initiatives/). Dr. Gary Brenner said recently, “I am highly optimistic that this gene therapy can represent an efficacious and safe therapy for patients with schwannoma – whether associated with NF2, schwannomatosis or sporadic tumours”. Gary J Brenner, MD, PhD, Associate Professor, Harvard Medical School. Director, Massachusetts General Hospital
- Your money will be used to fund the next step of Dr Brenner research: the toxicology study.
- In addition to Dr Brenner’s therapy, we are actively engaging gene therapy and NF2 researchers and clinicians to begin a gene replacement program that will essentially introduce a functional copy of the mutated NF2 gene back into the cells of NF2 patients.
- We’ve started to put together a worldwide network of outreach teams called the Ambassador Program. We are already in 15 locations in the world and still growing.
- We reached 1000+ followers of our facebook page.
- We will hold our first official fundraiser event “Axe Out NF2” on February 2, 2018 in USA Pennsylvania (West Chester) at Tilted Axes . We will throw axes at targets. It will be fun! More info soon!
- Our scientific advisory board and professional advisory board are growing, with the latest addition of Dr Joseph Kissil renowned NF2 researcher, Dr Yohay NF Neurologist and the serial entrepreneur/NF2er Onno Faber (RDMD).
- We are 100% volunteers and touched by NF2, so far we have virtually no overhead, no salaries and no operations costs.
Please donate below to benefit from US 2018 tax deductions.
You can be sure that we won’t stop until we save our kids! Have a wonderful Holiday!
NF2 BioSolutions Board
Yes ! We reached 1000 likes ! But we need volunteers, if you have skills that can help us to progress faster ( public relations , fundraising, finance , videographer , graphic designer, tax advisor etc... ). Let’s take our future into our hands! Comment here . Thank you!